Derek Zoolander is VH1's three time male model of the year, but when Hansel wins the award instead, Zoolander's world becomes upside down. His friends disappear, his father is disappointed in him, and he feels that he's not good as a model anymore. But when evil fashion guru Mugato hires Zoolander, he thinks his life has turned back round again, that is until he finds out that Mugato has actually brainwashed him to kill the Prime Minister of Malaysia. Can Zoolander and his new friends find out how to prevent the incident before it's too late?